These results suggested that depleting macrophages in mice abolished the differences in the immune responses induced by the flagellin variants FliC-L3A and FliC, which further confirmed that macrophages were the main effector cell that suppressed the TLR5-mediated adaptive immune response against flagellin by activating NLRC4. Open Acipimox in a separate window Figure 5 The different … Continue reading These results suggested that depleting macrophages in mice abolished the differences in the immune responses induced by the flagellin variants FliC-L3A and FliC, which further confirmed that macrophages were the main effector cell that suppressed the TLR5-mediated adaptive immune response against flagellin by activating NLRC4